Warm autoimmune hemolytic anemia with mimicking anti-c and -E specificities

H. Y. Hsieh, D. Moroney, D. Naumann, J. Hata, N. Vosnidou, R. Kessinger, N. Shahab, N. Hakami, Daniel Smith

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

An 18-month-old male was admitted to a hospital with a hemoglobin of 4.1 g/dL and a reticulocyte count of 53 percent. There was no history of prior transfusion. Serologic evaluation revealed the presence of both a positive direct antiglobulin test (DAT) and an indirect antiglobulin test (IAT). The patient's red blood cells (RBCs) typed as group A, C-D-E-c+e+ (cde/cde). Evaluation of the IAT revealed the presence of anti-c and anti-E. All other major antibodies were ruled out. Upon adsorption of the patient's serum with ficin-treated Cde/Cde RBCs, both antibody specificities were adsorbed; however, the antibodies were not adsorbed with native (untreated) Cde/Cde RBCs. Furthermore, the autoantibody was not adsorbed by Rhnull cells, thereby suggesting Rh specificity. The serum was incompatible with cde/cde RBCs and compatible with Cde/Cde RBCs. The patient was successfully transfused with Cde/Cde RBCs followed by resolution of his anemia, as evidenced by an increased and stable hemoglobin. It was concluded that the autoantibody had mimicking anti-c and -E specificities. This is a report of an unusual case of autoimmune hemolytic anemia because the Rh autoantibody appeared to have dual mimicking specificities, and the patient's RBCs were antigen negative for one of the antibody specificities, i.e., anti-E.

Original languageEnglish (US)
Pages (from-to)19-22
Number of pages4
JournalImmunohematology
Volume18
Issue number1
StatePublished - 2002
Externally publishedYes

Fingerprint

Autoimmune Hemolytic Anemia
Erythrocytes
Coombs Test
Autoantibodies
Antibody Specificity
Hemoglobins
Ficain
Reticulocyte Count
Dilatation and Curettage
Antibodies
Serum
Adsorption
Anemia
Antigens

Keywords

  • Autoimmune hemolytic anemia
  • Rh mimicking antibodies

ASJC Scopus subject areas

  • Immunology
  • Hematology

Cite this

Hsieh, H. Y., Moroney, D., Naumann, D., Hata, J., Vosnidou, N., Kessinger, R., ... Smith, D. (2002). Warm autoimmune hemolytic anemia with mimicking anti-c and -E specificities. Immunohematology, 18(1), 19-22.

Warm autoimmune hemolytic anemia with mimicking anti-c and -E specificities. / Hsieh, H. Y.; Moroney, D.; Naumann, D.; Hata, J.; Vosnidou, N.; Kessinger, R.; Shahab, N.; Hakami, N.; Smith, Daniel.

In: Immunohematology, Vol. 18, No. 1, 2002, p. 19-22.

Research output: Contribution to journalArticle

Hsieh, HY, Moroney, D, Naumann, D, Hata, J, Vosnidou, N, Kessinger, R, Shahab, N, Hakami, N & Smith, D 2002, 'Warm autoimmune hemolytic anemia with mimicking anti-c and -E specificities', Immunohematology, vol. 18, no. 1, pp. 19-22.
Hsieh HY, Moroney D, Naumann D, Hata J, Vosnidou N, Kessinger R et al. Warm autoimmune hemolytic anemia with mimicking anti-c and -E specificities. Immunohematology. 2002;18(1):19-22.
Hsieh, H. Y. ; Moroney, D. ; Naumann, D. ; Hata, J. ; Vosnidou, N. ; Kessinger, R. ; Shahab, N. ; Hakami, N. ; Smith, Daniel. / Warm autoimmune hemolytic anemia with mimicking anti-c and -E specificities. In: Immunohematology. 2002 ; Vol. 18, No. 1. pp. 19-22.
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