Waveform parameters of retrobulbar vessels in glaucoma patients with different demographics and disease severity

Lucia Carichino, Alon Harris, Sergey Lapin, Giovanna Guidoboni, Simone Cassani, Annalisa De Silvestri, Carmine Tinelli, Giovanni Milano, Brent Siesky, Alice C. Verticchio Vercellin

Research output: Contribution to journalArticle

Abstract

Introduction: To identify novel velocity waveform parameters of the ophthalmic artery and central retinal artery by computer-aided image processing of Doppler ultrasonography measurements, and to evaluate correlations between the waveform parameters and different demographics and disease severity of open-angle glaucoma patients. Methods: Thirty-six images of 36 open-angle glaucoma patients were considered. A semiautomated image processing code was used to detect the digitalized ophthalmic artery and central retinal artery velocity waveforms and to extract the waveform parameters. Concordance correlation coefficient, two-sample t-test, and Pearson’s correlation coefficient were used to test for similarities, differences, and associations among variables. Results: Female glaucoma patients showed a statistically higher ophthalmic artery normalized distance between ascending and descending limb (p = 0.004), hypertensive glaucoma patients a statistically higher ophthalmic artery peak systolic velocity time (p = 0.025), glaucoma patients with hyperlipidemia a statistically higher ophthalmic artery resistivity index (p = 0.023) and a statistically higher ophthalmic artery peak systolic velocity acceleration (p = 0.025), glaucoma patients with cardiovascular diseases a statistically lower central retinal artery normalized distance between ascending and descending limb of the wave (p = 0.033) and a statistically higher central retinal artery period (p = 0.028), and patients with different body mass index a statistically different central retinal artery normalized distance between ascending and descending limb of the wave (p = 0.016). Groups with different disease severity, classified following the Brusini glaucoma staging system 2, showed statistically different central retinal artery normalized distance between ascending and descending limb of the wave (p < 0.001) and central retinal artery period (p = 0.016). No statistical differences were found in regard to race, diabetes status, glaucoma family history, and smoking. Discussion: Ophthalmic artery and central retinal artery computer-aided analysis of velocity waveforms could identify novel waveform parameters capable of differentiating among different demographics and disease severity of open-angle glaucoma patients.

Original languageEnglish (US)
JournalEuropean Journal of Ophthalmology
DOIs
StatePublished - Jan 1 2019

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Retinal Artery
Ophthalmic Artery
Glaucoma
Demography
Open Angle Glaucoma
Extremities
Doppler Ultrasonography
Hyperlipidemias
Body Mass Index
Cardiovascular Diseases
Smoking

Keywords

  • Disease progression
  • Doppler ultrasonography
  • glaucoma
  • image processing
  • imaging
  • velocity
  • waveform parameters

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Waveform parameters of retrobulbar vessels in glaucoma patients with different demographics and disease severity. / Carichino, Lucia; Harris, Alon; Lapin, Sergey; Guidoboni, Giovanna; Cassani, Simone; De Silvestri, Annalisa; Tinelli, Carmine; Milano, Giovanni; Siesky, Brent; Verticchio Vercellin, Alice C.

In: European Journal of Ophthalmology, 01.01.2019.

Research output: Contribution to journalArticle

Carichino, Lucia ; Harris, Alon ; Lapin, Sergey ; Guidoboni, Giovanna ; Cassani, Simone ; De Silvestri, Annalisa ; Tinelli, Carmine ; Milano, Giovanni ; Siesky, Brent ; Verticchio Vercellin, Alice C. / Waveform parameters of retrobulbar vessels in glaucoma patients with different demographics and disease severity. In: European Journal of Ophthalmology. 2019.
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AU - Lapin, Sergey

AU - Guidoboni, Giovanna

AU - Cassani, Simone

AU - De Silvestri, Annalisa

AU - Tinelli, Carmine

AU - Milano, Giovanni

AU - Siesky, Brent

AU - Verticchio Vercellin, Alice C.

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