Abstract
How stones are retained within the kidney while small in size is still not fully understood. In this paper, we show two examples of how stones are retained during early growth: one is growth on Randall’s (interstitial) plaque, and the other is growth on mineral that has formed as a luminal plug in a terminal collecting duct. These two mechanisms of stone retention during early growth have distinctive morphologic features that can be seen by methods that show the microscopic structure of the stones. Stones growing on Randall’s plaque display an apatite region that is typically not large in size (<0.5 mm across) but which usually shows luminal spaces, which are signs of its origin in the connective tissue of the papilla. Stones growing on ductal plugs also show attachment to a piece of apatite, but the apatite regions are typically larger (often >1 mm long and >0.5 mm wide), and they are solid, without spaces running through them. We propose that knowing the mechanisms of stone retention during early stone formation could allow for better treatment of stone diseases.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-7 |
| Number of pages | 7 |
| Journal | Urolithiasis |
| DOIs | |
| State | Accepted/In press - Dec 2 2016 |
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Keywords
- Imaging
- Nephrolithiasis
ASJC Scopus subject areas
- Urology
Cite this
What can the microstructure of stones tell us? / Williams, James; Worcester, Elaine; Lingeman, James E.
In: Urolithiasis, 02.12.2016, p. 1-7.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - What can the microstructure of stones tell us?
AU - Williams, James
AU - Worcester, Elaine
AU - Lingeman, James E.
PY - 2016/12/2
Y1 - 2016/12/2
N2 - How stones are retained within the kidney while small in size is still not fully understood. In this paper, we show two examples of how stones are retained during early growth: one is growth on Randall’s (interstitial) plaque, and the other is growth on mineral that has formed as a luminal plug in a terminal collecting duct. These two mechanisms of stone retention during early growth have distinctive morphologic features that can be seen by methods that show the microscopic structure of the stones. Stones growing on Randall’s plaque display an apatite region that is typically not large in size (<0.5 mm across) but which usually shows luminal spaces, which are signs of its origin in the connective tissue of the papilla. Stones growing on ductal plugs also show attachment to a piece of apatite, but the apatite regions are typically larger (often >1 mm long and >0.5 mm wide), and they are solid, without spaces running through them. We propose that knowing the mechanisms of stone retention during early stone formation could allow for better treatment of stone diseases.
AB - How stones are retained within the kidney while small in size is still not fully understood. In this paper, we show two examples of how stones are retained during early growth: one is growth on Randall’s (interstitial) plaque, and the other is growth on mineral that has formed as a luminal plug in a terminal collecting duct. These two mechanisms of stone retention during early growth have distinctive morphologic features that can be seen by methods that show the microscopic structure of the stones. Stones growing on Randall’s plaque display an apatite region that is typically not large in size (<0.5 mm across) but which usually shows luminal spaces, which are signs of its origin in the connective tissue of the papilla. Stones growing on ductal plugs also show attachment to a piece of apatite, but the apatite regions are typically larger (often >1 mm long and >0.5 mm wide), and they are solid, without spaces running through them. We propose that knowing the mechanisms of stone retention during early stone formation could allow for better treatment of stone diseases.
KW - Imaging
KW - Nephrolithiasis
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UR - http://www.scopus.com/inward/citedby.url?scp=85000956386&partnerID=8YFLogxK
U2 - 10.1007/s00240-016-0944-z
DO - 10.1007/s00240-016-0944-z
M3 - Article
C2 - 27913855
AN - SCOPUS:85000956386
SP - 1
EP - 7
JO - Urolithiasis
JF - Urolithiasis
SN - 2194-7228
ER -