What causes severe malaria and its complications in children? Lessons learned over the past 15 years 11 Medical and Health Sciences 1108 Medical Microbiology

Andrea L. Conroy, Dibyadyuti Datta, Chandy John

Research output: Contribution to journalArticle

Abstract

Over the past 15 years, malaria mortality has reduced by approximately 50%. However, malaria still causes more than 400,000 deaths annually, most of which occur in African children under 5 years of age. Significant advances in understanding the pathogenesis of the disease provide a basis for future work to prevent severe malaria and its complications. Herein, we provide an overview of advances in our understanding of severe malaria in African children over the past 15 years, highlighting key complications and identifying priorities to further reduce malaria-associated mortality.

Original languageEnglish (US)
Article number52
JournalBMC medicine
Volume17
Issue number1
DOIs
StatePublished - Mar 7 2019

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Microbiology
Malaria
Health
Mortality

Keywords

  • Acute kidney injury
  • Cerebral malaria
  • Cognitive
  • Impairment
  • Neurodevelopmental
  • Pathogenesis
  • Plasmodium falciparum
  • Severe malaria
  • Severe malarial anemia

ASJC Scopus subject areas

  • Medicine(all)

Cite this

What causes severe malaria and its complications in children? Lessons learned over the past 15 years 11 Medical and Health Sciences 1108 Medical Microbiology. / Conroy, Andrea L.; Datta, Dibyadyuti; John, Chandy.

In: BMC medicine, Vol. 17, No. 1, 52, 07.03.2019.

Research output: Contribution to journalArticle

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