What causes severe malaria and its complications in children? Lessons learned over the past

Andrea L. Conroy, Dibyadyuti Datta, Chandy C. John

Research output: Contribution to journalArticle

4 Scopus citations


Over the past 15 years, malaria mortality has reduced by approximately 50%. However, malaria still causes more than 400,000 deaths annually, most of which occur in African children under 5 years of age. Significant advances in understanding the pathogenesis of the disease provide a basis for future work to prevent severe malaria and its complications. Herein, we provide an overview of advances in our understanding of severe malaria in African children over the past 15 years, highlighting key complications and identifying priorities to further reduce malaria-associated mortality.

Original languageEnglish (US)
Article number52
JournalBMC medicine
Issue number1
StatePublished - Mar 7 2019



  • Acute kidney injury
  • Cerebral malaria
  • Cognitive
  • Impairment
  • Neurodevelopmental
  • Pathogenesis
  • Plasmodium falciparum
  • Severe malaria
  • Severe malarial anemia

ASJC Scopus subject areas

  • Medicine(all)

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