Where to focus efforts to reduce the black-white disparity in stroke mortality: Incidence versus case fatality?

George Howard, Claudia S. Moy, Virginia J. Howard, Leslie A. McClure, Dawn O. Kleindorfer, Brett M. Kissela, Suzanne E. Judd, Fredrick W. Unverzagt, Elsayed Z. Soliman, Monika M. Safford, Mary Cushman, Matthew L. Flaherty, Virginia G. Wadley

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Background and Purpose - At age 45 years, blacks have a stroke mortality ≈3× greater than their white counterparts, with a declining disparity at older ages. We assess whether this black-white disparity in stroke mortality is attributable to a black-white disparity in stroke incidence versus a disparity in case fatality. Methods - We first assess if black-white differences in stroke mortality within 29 681 participants in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort reflect national black-white differences in stroke mortality and then assess the degree to which black-white differences in stroke incidence or 30-day case fatality after stroke contribute to the disparities in stroke mortality. Results - The pattern of stroke mortality within the study mirrors the national pattern, with the black-to-white hazard ratio of ≈4.0 at age 45 years decreasing to ≈1.0 at age 85 years. The pattern of black-to-white disparities in stroke incidence shows a similar pattern but no evidence of a corresponding disparity in stroke case fatality. Conclusions - These findings show that the black-white differences in stroke mortality are largely driven by differences in stroke incidence, with case fatality playing at most a minor role. Therefore, to reduce the black-white disparity in stroke mortality, interventions need to focus on prevention of stroke in blacks.

Original languageEnglish (US)
Pages (from-to)1893-1898
Number of pages6
JournalStroke
Volume47
Issue number7
DOIs
StatePublished - Jul 1 2016

Keywords

  • blacks
  • continental population groups
  • incidence
  • mortality
  • stroke

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

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    Howard, G., Moy, C. S., Howard, V. J., McClure, L. A., Kleindorfer, D. O., Kissela, B. M., Judd, S. E., Unverzagt, F. W., Soliman, E. Z., Safford, M. M., Cushman, M., Flaherty, M. L., & Wadley, V. G. (2016). Where to focus efforts to reduce the black-white disparity in stroke mortality: Incidence versus case fatality? Stroke, 47(7), 1893-1898. https://doi.org/10.1161/STROKEAHA.115.012631