White blood cell aplasia associated with thymoma

S. P. Ackland, M. E. Bur, S. S. Adler, M. Robertson, J. M. Baron

Research output: Contribution to journalArticle

16 Scopus citations


A limited number of cases of acquired hypoplastic neutropenia or pure white blood cell aplasia (PWCA) associated with thymoma have been reported, in contrast to the well-documented association of pure red blood cell aplasia and thymoma. The mechanism of the aplasia in these disorders is unclear. The authors report a case of PWCA (with total absence of all granulopoietic elements in the bone marrow) in a patient with metastatic spindle cell thymoma, in which suppression of autologous granulocyte-macrophage colony-forming units by the patient's serum could be demonstrated. This finding suggests a humoral autoimmune mechanism for the pathogenesis of PWCA in this patient and lends support to the possibility that all hematologic phenomena associated with thymoma may have an autoimmune basis.

Original languageEnglish (US)
Pages (from-to)260-263
Number of pages4
JournalAmerican journal of clinical pathology
Issue number2
StatePublished - Jan 1 1988
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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