White matter abnormalities of microstructure and physiological noise in schizophrenia

Hu Cheng, Sharlene D. Newman, Jerillyn S. Kent, Amanda Bolbecker, Mallory J. Klaunig, Brian O'Donnell, Aina Puce, William P. Hetrick

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

White matter abnormalities in schizophrenia have been revealed by many imaging techniques and analysis methods. One of the findings by diffusion tensor imaging is a decrease in fractional anisotropy (FA), which is an indicator of white matter integrity. On the other hand, elevation of metabolic rate in white matter was observed from positron emission tomography (PET) studies. In this report, we aim to compare the two structural and functional effects on the same subjects. Our comparison is based on the hypothesis that signal fluctuation in white matter is associated with white matter functional activity. We examined the variance of the signal in resting state fMRI and found significant differences between individuals with schizophrenia and non-psychiatric controls specifically in white matter tissue. Controls showed higher temporal signal-to-noise ratios clustered in regions including temporal, frontal, and parietal lobes, cerebellum, corpus callosum, superior longitudinal fasciculus, and other major white matter tracts. These regions with higher temporal signal-to-noise ratio agree well with those showing higher metabolic activity reported by studies using PET. The results suggest that individuals with schizophrenia tend to have higher functional activity in white matter in certain brain regions relative to healthy controls. Despite some overlaps, the distinct regions for physiological noise are different from those for FA derived from diffusion tensor imaging, and therefore provide a unique angle to explore potential mechanisms to white matter abnormality.

Original languageEnglish (US)
Pages (from-to)868-877
Number of pages10
JournalBrain Imaging and Behavior
Volume9
Issue number4
DOIs
StatePublished - Dec 1 2015

Fingerprint

Noise
Schizophrenia
Diffusion Tensor Imaging
Anisotropy
Signal-To-Noise Ratio
Positron-Emission Tomography
White Matter
Parietal Lobe
Corpus Callosum
Frontal Lobe
Temporal Lobe
Individuality
Cerebellum
Magnetic Resonance Imaging
Brain

Keywords

  • Physiological noise
  • Resting state fMRI
  • Schizophrenia
  • White matter

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Behavioral Neuroscience
  • Cellular and Molecular Neuroscience
  • Cognitive Neuroscience
  • Neurology
  • Psychiatry and Mental health
  • Clinical Neurology

Cite this

Cheng, H., Newman, S. D., Kent, J. S., Bolbecker, A., Klaunig, M. J., O'Donnell, B., ... Hetrick, W. P. (2015). White matter abnormalities of microstructure and physiological noise in schizophrenia. Brain Imaging and Behavior, 9(4), 868-877. https://doi.org/10.1007/s11682-014-9349-1

White matter abnormalities of microstructure and physiological noise in schizophrenia. / Cheng, Hu; Newman, Sharlene D.; Kent, Jerillyn S.; Bolbecker, Amanda; Klaunig, Mallory J.; O'Donnell, Brian; Puce, Aina; Hetrick, William P.

In: Brain Imaging and Behavior, Vol. 9, No. 4, 01.12.2015, p. 868-877.

Research output: Contribution to journalArticle

Cheng, H, Newman, SD, Kent, JS, Bolbecker, A, Klaunig, MJ, O'Donnell, B, Puce, A & Hetrick, WP 2015, 'White matter abnormalities of microstructure and physiological noise in schizophrenia', Brain Imaging and Behavior, vol. 9, no. 4, pp. 868-877. https://doi.org/10.1007/s11682-014-9349-1
Cheng, Hu ; Newman, Sharlene D. ; Kent, Jerillyn S. ; Bolbecker, Amanda ; Klaunig, Mallory J. ; O'Donnell, Brian ; Puce, Aina ; Hetrick, William P. / White matter abnormalities of microstructure and physiological noise in schizophrenia. In: Brain Imaging and Behavior. 2015 ; Vol. 9, No. 4. pp. 868-877.
@article{7d508cee6e764572b4d530bb058b5043,
title = "White matter abnormalities of microstructure and physiological noise in schizophrenia",
abstract = "White matter abnormalities in schizophrenia have been revealed by many imaging techniques and analysis methods. One of the findings by diffusion tensor imaging is a decrease in fractional anisotropy (FA), which is an indicator of white matter integrity. On the other hand, elevation of metabolic rate in white matter was observed from positron emission tomography (PET) studies. In this report, we aim to compare the two structural and functional effects on the same subjects. Our comparison is based on the hypothesis that signal fluctuation in white matter is associated with white matter functional activity. We examined the variance of the signal in resting state fMRI and found significant differences between individuals with schizophrenia and non-psychiatric controls specifically in white matter tissue. Controls showed higher temporal signal-to-noise ratios clustered in regions including temporal, frontal, and parietal lobes, cerebellum, corpus callosum, superior longitudinal fasciculus, and other major white matter tracts. These regions with higher temporal signal-to-noise ratio agree well with those showing higher metabolic activity reported by studies using PET. The results suggest that individuals with schizophrenia tend to have higher functional activity in white matter in certain brain regions relative to healthy controls. Despite some overlaps, the distinct regions for physiological noise are different from those for FA derived from diffusion tensor imaging, and therefore provide a unique angle to explore potential mechanisms to white matter abnormality.",
keywords = "Physiological noise, Resting state fMRI, Schizophrenia, White matter",
author = "Hu Cheng and Newman, {Sharlene D.} and Kent, {Jerillyn S.} and Amanda Bolbecker and Klaunig, {Mallory J.} and Brian O'Donnell and Aina Puce and Hetrick, {William P.}",
year = "2015",
month = "12",
day = "1",
doi = "10.1007/s11682-014-9349-1",
language = "English (US)",
volume = "9",
pages = "868--877",
journal = "Brain Imaging and Behavior",
issn = "1931-7557",
publisher = "Springer New York",
number = "4",

}

TY - JOUR

T1 - White matter abnormalities of microstructure and physiological noise in schizophrenia

AU - Cheng, Hu

AU - Newman, Sharlene D.

AU - Kent, Jerillyn S.

AU - Bolbecker, Amanda

AU - Klaunig, Mallory J.

AU - O'Donnell, Brian

AU - Puce, Aina

AU - Hetrick, William P.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - White matter abnormalities in schizophrenia have been revealed by many imaging techniques and analysis methods. One of the findings by diffusion tensor imaging is a decrease in fractional anisotropy (FA), which is an indicator of white matter integrity. On the other hand, elevation of metabolic rate in white matter was observed from positron emission tomography (PET) studies. In this report, we aim to compare the two structural and functional effects on the same subjects. Our comparison is based on the hypothesis that signal fluctuation in white matter is associated with white matter functional activity. We examined the variance of the signal in resting state fMRI and found significant differences between individuals with schizophrenia and non-psychiatric controls specifically in white matter tissue. Controls showed higher temporal signal-to-noise ratios clustered in regions including temporal, frontal, and parietal lobes, cerebellum, corpus callosum, superior longitudinal fasciculus, and other major white matter tracts. These regions with higher temporal signal-to-noise ratio agree well with those showing higher metabolic activity reported by studies using PET. The results suggest that individuals with schizophrenia tend to have higher functional activity in white matter in certain brain regions relative to healthy controls. Despite some overlaps, the distinct regions for physiological noise are different from those for FA derived from diffusion tensor imaging, and therefore provide a unique angle to explore potential mechanisms to white matter abnormality.

AB - White matter abnormalities in schizophrenia have been revealed by many imaging techniques and analysis methods. One of the findings by diffusion tensor imaging is a decrease in fractional anisotropy (FA), which is an indicator of white matter integrity. On the other hand, elevation of metabolic rate in white matter was observed from positron emission tomography (PET) studies. In this report, we aim to compare the two structural and functional effects on the same subjects. Our comparison is based on the hypothesis that signal fluctuation in white matter is associated with white matter functional activity. We examined the variance of the signal in resting state fMRI and found significant differences between individuals with schizophrenia and non-psychiatric controls specifically in white matter tissue. Controls showed higher temporal signal-to-noise ratios clustered in regions including temporal, frontal, and parietal lobes, cerebellum, corpus callosum, superior longitudinal fasciculus, and other major white matter tracts. These regions with higher temporal signal-to-noise ratio agree well with those showing higher metabolic activity reported by studies using PET. The results suggest that individuals with schizophrenia tend to have higher functional activity in white matter in certain brain regions relative to healthy controls. Despite some overlaps, the distinct regions for physiological noise are different from those for FA derived from diffusion tensor imaging, and therefore provide a unique angle to explore potential mechanisms to white matter abnormality.

KW - Physiological noise

KW - Resting state fMRI

KW - Schizophrenia

KW - White matter

UR - http://www.scopus.com/inward/record.url?scp=84948588256&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84948588256&partnerID=8YFLogxK

U2 - 10.1007/s11682-014-9349-1

DO - 10.1007/s11682-014-9349-1

M3 - Article

VL - 9

SP - 868

EP - 877

JO - Brain Imaging and Behavior

JF - Brain Imaging and Behavior

SN - 1931-7557

IS - 4

ER -