White matter alterations in early-stage Alzheimer's disease

A tract-specific study

Qiuting Wen, Sourajit M. Mustafi, Junjie Li, Shannon L. Risacher, Eileen Tallman, Steven A. Brown, John D. West, Jaroslaw Harezlak, Martin Farlow, Frederick Unverzagt, Sujuan Gao, Liana G. Apostolova, Andrew Saykin, Yu Chien Wu

Research output: Contribution to journalArticle

Abstract

Introduction: Diffusion magnetic resonance imaging may allow for microscopic characterization of white matter degeneration in early stages of Alzheimer's disease. Methods: Multishell Diffusion magnetic resonance imaging data were acquired from 100 participants (40 cognitively normal, 38 with subjective cognitive decline, and 22 with mild cognitive impairment [MCI]). White matter microscopic degeneration in 27 major tracts of interest was assessed using diffusion tensor imaging (DTI), neurite orientation dispersion and density imaging, and q-space imaging. Results: Lower DTI fractional anisotropy and higher radial diffusivity were observed in the cingulum, thalamic radiation, and forceps major of participants with MCI. These tracts of interest also had the highest predictive power to discriminate groups. Diffusion metrics were associated with cognitive performance, particularly Rey Auditory Verbal Learning Test immediate recall, with the highest association observed in participants with MCI. Discussion: While DTI was the most sensitive, neurite orientation dispersion and density imaging and q-space imaging complementarily characterized reduced axonal density accompanied with dispersed and less restricted white matter microstructures.

Original languageEnglish (US)
Pages (from-to)576-587
Number of pages12
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume11
DOIs
StatePublished - Dec 1 2019

Fingerprint

Diffusion Tensor Imaging
Alzheimer Disease
Magnetic Resonance Imaging
Diffusion Magnetic Resonance Imaging
Neurites
Verbal Learning
Anisotropy
Short-Term Memory
Surgical Instruments
Radiation
White Matter
Cognitive Dysfunction

Keywords

  • Alzheimer's disease
  • Diffusion imaging
  • diffusion tensor imaging
  • Magnetic resonance imaging
  • MCI
  • NODDI
  • SCD
  • Tract
  • Tractography
  • White matter

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

White matter alterations in early-stage Alzheimer's disease : A tract-specific study. / Wen, Qiuting; Mustafi, Sourajit M.; Li, Junjie; Risacher, Shannon L.; Tallman, Eileen; Brown, Steven A.; West, John D.; Harezlak, Jaroslaw; Farlow, Martin; Unverzagt, Frederick; Gao, Sujuan; Apostolova, Liana G.; Saykin, Andrew; Wu, Yu Chien.

In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, Vol. 11, 01.12.2019, p. 576-587.

Research output: Contribution to journalArticle

Wen, Qiuting ; Mustafi, Sourajit M. ; Li, Junjie ; Risacher, Shannon L. ; Tallman, Eileen ; Brown, Steven A. ; West, John D. ; Harezlak, Jaroslaw ; Farlow, Martin ; Unverzagt, Frederick ; Gao, Sujuan ; Apostolova, Liana G. ; Saykin, Andrew ; Wu, Yu Chien. / White matter alterations in early-stage Alzheimer's disease : A tract-specific study. In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 2019 ; Vol. 11. pp. 576-587.
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