White matter injury in spinal cord ischemia

Protection by AMPA/kainate glutamate receptor antagonism

Georgios K. Kanellopoulos, Xiao-Ming Xu, Chung Y. Hsu, Xiaobin Lu, Thoralf M. Sundt, Nicholas T. Kouchoukos

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

Background and Purpose - Spinal cord ischemia is a serious complication of surgery of the aorta. NMDA receptor activation secondary to ischemia-induced release of glutamate is a major mechanism of neuronal death in gray matter. White matter injury after ischemia results in long-tract dysfunction and disability. The AMPA/kainate receptor mechanism has recently been implicated in white matter injury. Methods - We studied the effects of AMPA/kainate receptor blockade on ischemic white matter injury in a rat model of spinal cord ischemia. Results - Intrathecal administration of an AMPA/kainate antagonist, 6-nitro-7-sulfamoyl-(f)-quinoxaline-2,3-dione (NBQX), 1 hour before ischemia reduced locomotor deficit, based on the Basso-Beattie-Bresnahan scale (0=total paralysis; 21=normal) (sham: 21±0, n=3; saline: 3.7±4.5, n=7; NBQX: 12.7±7.0, n=7, P

Original languageEnglish (US)
Pages (from-to)1945-1952
Number of pages8
JournalStroke
Volume31
Issue number8
StatePublished - 2000
Externally publishedYes

Fingerprint

Spinal Cord Ischemia
Kainic Acid Receptors
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Glutamate Receptors
AMPA Receptors
Ischemia
Wounds and Injuries
Quinoxalines
Kainic Acid
N-Methyl-D-Aspartate Receptors
Paralysis
Aorta
Glutamic Acid
White Matter
2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline

Keywords

  • Aorta
  • Axons
  • Excitotoxins
  • Myelin
  • Paraplegia
  • Rats
  • Spinal cord

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Kanellopoulos, G. K., Xu, X-M., Hsu, C. Y., Lu, X., Sundt, T. M., & Kouchoukos, N. T. (2000). White matter injury in spinal cord ischemia: Protection by AMPA/kainate glutamate receptor antagonism. Stroke, 31(8), 1945-1952.

White matter injury in spinal cord ischemia : Protection by AMPA/kainate glutamate receptor antagonism. / Kanellopoulos, Georgios K.; Xu, Xiao-Ming; Hsu, Chung Y.; Lu, Xiaobin; Sundt, Thoralf M.; Kouchoukos, Nicholas T.

In: Stroke, Vol. 31, No. 8, 2000, p. 1945-1952.

Research output: Contribution to journalArticle

Kanellopoulos, GK, Xu, X-M, Hsu, CY, Lu, X, Sundt, TM & Kouchoukos, NT 2000, 'White matter injury in spinal cord ischemia: Protection by AMPA/kainate glutamate receptor antagonism', Stroke, vol. 31, no. 8, pp. 1945-1952.
Kanellopoulos GK, Xu X-M, Hsu CY, Lu X, Sundt TM, Kouchoukos NT. White matter injury in spinal cord ischemia: Protection by AMPA/kainate glutamate receptor antagonism. Stroke. 2000;31(8):1945-1952.
Kanellopoulos, Georgios K. ; Xu, Xiao-Ming ; Hsu, Chung Y. ; Lu, Xiaobin ; Sundt, Thoralf M. ; Kouchoukos, Nicholas T. / White matter injury in spinal cord ischemia : Protection by AMPA/kainate glutamate receptor antagonism. In: Stroke. 2000 ; Vol. 31, No. 8. pp. 1945-1952.
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