White specks in the esophageal mucosa: An endoscopic manifestation of non-reflux eosinophilic esophagitis in children

Joel R. Lim, Sandeep K. Gupta, Joseph M. Croffie, Marian D. Pfefferkorn, Jean P. Molleston, Mark R. Corkins, Mary M. Davis, Philip P. Faught, Steven J. Steiner, Joseph F. Fitzgerald

Research output: Contribution to journalArticle

90 Scopus citations


Background White specks in the esophageal mucosa have been observed in children with eosinophilic esophagitis. The aim of this study was to determine the relationship between white specks in the esophageal mucosa and allergic (non-reflux) eosinophilic esophagitis. Methods Endoscopic data, pH probe results, and histopathology reports for children with esophageal endoscopic abnormalities seen during a 17-month period were reviewed. Eosinophilic esophagitis was grouped according to the number of eosinophils per high power field (non-allergic, <15 eosinophils/high power field; allergic, ≥15 eosinophils/high power field). Results Of 1041 endoscopies performed during the study period, 153 revealed evidence of eosinophilic esophagitis. Of these 153, 61 had fewer than 15 eosinophils/high power field and 92 had 15 or more eosinophils/high power field. At 31 of the 153 procedures, white specks were noted in the esophageal mucosa. The sensitivity of white specks in the esophageal mucosa for allergic eosinophilic esophagitis was only 30%, but the specificity was 95%. pH probe testing was performed in 21 patients with white specks and was normal in all. Conclusions This report describes a new endoscopic finding associated with allergic eosinophilic esophagitis in children. Eosinophilic esophagitis tends to be severe when white specks are present (≥15 eosinophils/high power field) and is not associated with pathologic gastroesophageal reflux, as demonstrated by pH probe testing.

Original languageEnglish (US)
Pages (from-to)835-838
Number of pages4
JournalGastrointestinal endoscopy
Issue number7
StatePublished - Jun 2004

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

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