Whole Exome and Transcriptome Sequencing in 1042 Cases Reveals Distinct Clinically Relevant Genetic Subgroups of Follicular Lymphoma

Xiang Li, Rachel Kositsky, Anupama Reddy, Cassandra Love, Kikkeri Naresh, Jean L. Koff, Ilja Nystrand, Sirpa Leppä, Annika Pasanen, Marja Liisa Karjalainen-Lindsberg, Johannes Dunkel, Panu Kovanen, Qiu Qin, Govind Bhagat, Rebecca J. Leeman-Neill, Rashmi S. Goswami, Sarah Wildeman, Jan Delabie, Richard Burack, Andrew G. EvansCatalina Amador, Ji Yuan, Hina Naushad Qureishi, Shaoying Li, Jie Xu, C. Cameron Yin, Anne Ortved Gang, Peter H. Norgaard, Mette Pedersen, Jason Yongsheng Chan, Daryl Ming Zhe Cheah, Shin Yeu Ong, Chee Leong Cheng, Lianne Lee, Felik Paulua, Sarah L. Ondrejka, Eric D. Hsi, Magdalena Czader, Lin Wang, Amber Landis, Michael C. Churnetski, David L. Jaye, Christopher R. Flowers, Chad M. McCall, Jadee Neff, Matthew S. McKinney, Yuri Fedoriw, Eric Powers, Nathan D. Montgomery, Agata M. Bogusz, Andrea Stafford Hintz, Alexandra E. Kovach, Nishitha Reddy, Mary Ann Thompson Arildsen, Emily F. Mason, Ridas Juskevicius, William Choi, Rex Au-Yeung, Eric Tse, Vincent Sarno, Amy Chadburn, Rafael Lopez, Jennifer R. Chapman, Amir Behdad, Neta Goldschmidt, John Goodlad, Cathy Burton, Raju Pillai, Abner Louissaint, Dina Sameh Soliman, Razvan Panea, Tushar Dave, Barbara Xiong, Eileen Smith, Sandeep Dave

Research output: Contribution to journalArticle

Abstract

DISCLOSURES: Koff: Burroughs Wellcome Fund: Research Funding; V Foundation: Research Funding; Lymphoma Research Foundation: Research Funding; American Association for Cancer Research: Research Funding. Leppä:Roche: Honoraria, Research Funding; Takeda: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Bayer: Research Funding; Celgene: Membership on an entity's Board of Directors or advisory committees, Research Funding; Janssen-Cilag: Research Funding; Novartis: Membership on an entity's Board of Directors or advisory committees. Gang:ROCHE: Membership on an entity's Board of Directors or advisory committees; Novartis: Membership on an entity's Board of Directors or advisory committees. Hsi:Abbvie: Research Funding; Eli Lilly: Research Funding; Cleveland Clinic&Abbvie Biotherapeutics Inc: Patents & Royalties: US8,603,477 B2; Jazz: Consultancy. Flowers:AbbVie: Consultancy, Research Funding; Denovo Biopharma: Consultancy; BeiGene: Consultancy, Research Funding; Burroughs Wellcome Fund: Research Funding; Eastern Cooperative Oncology Group: Research Funding; National Cancer Institute: Research Funding; V Foundation: Research Funding; Optimum Rx: Consultancy; Millenium/Takeda: Research Funding; TG Therapeutics: Research Funding; Gilead: Consultancy, Research Funding; Celgene: Consultancy, Research Funding; Karyopharm: Consultancy; AstraZeneca: Consultancy; Pharmacyclics/Janssen: Consultancy, Research Funding; Spectrum: Consultancy; Bayer: Consultancy; Acerta: Research Funding; Genentech, Inc./F. Hoffmann-La Roche Ltd: Consultancy, Research Funding. Neff:Enzyvant: Consultancy; EUSA Pharma: Honoraria, Membership on an entity's Board of Directors or advisory committees. Fedoriw:Alexion Pharmaceuticals: Other: Consultant and Speaker. Reddy:Genentech: Research Funding; BMS: Consultancy, Research Funding; Celgene: Consultancy; KITE Pharma: Consultancy; Abbvie: Consultancy. Mason:Sysmex: Honoraria. Behdad:Loxo-Bayer: Membership on an entity's Board of Directors or advisory committees; Thermo Fisher: Membership on an entity's Board of Directors or advisory committees; Pfizer: Other: Speaker. Burton:Bristol-Myers Squibb: Honoraria, Membership on an entity's Board of Directors or advisory committees; Roche: Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: Travel; Celgene: Membership on an entity's Board of Directors or advisory committees; Takeda: Honoraria, Membership on an entity's Board of Directors or advisory committees. Dave:Data Driven Bioscience: Equity Ownership.

Original languageEnglish (US)
Number of pages1
JournalBlood
Volume134
Issue number1
DOIs
StatePublished - Nov 13 2019

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Exome
Follicular Lymphoma
Transcriptome
Advisory Committees
Research

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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Whole Exome and Transcriptome Sequencing in 1042 Cases Reveals Distinct Clinically Relevant Genetic Subgroups of Follicular Lymphoma. / Li, Xiang; Kositsky, Rachel; Reddy, Anupama; Love, Cassandra; Naresh, Kikkeri; Koff, Jean L.; Nystrand, Ilja; Leppä, Sirpa; Pasanen, Annika; Karjalainen-Lindsberg, Marja Liisa; Dunkel, Johannes; Kovanen, Panu; Qin, Qiu; Bhagat, Govind; Leeman-Neill, Rebecca J.; Goswami, Rashmi S.; Wildeman, Sarah; Delabie, Jan; Burack, Richard; Evans, Andrew G.; Amador, Catalina; Yuan, Ji; Qureishi, Hina Naushad; Li, Shaoying; Xu, Jie; Yin, C. Cameron; Gang, Anne Ortved; Norgaard, Peter H.; Pedersen, Mette; Chan, Jason Yongsheng; Cheah, Daryl Ming Zhe; Ong, Shin Yeu; Cheng, Chee Leong; Lee, Lianne; Paulua, Felik; Ondrejka, Sarah L.; Hsi, Eric D.; Czader, Magdalena; Wang, Lin; Landis, Amber; Churnetski, Michael C.; Jaye, David L.; Flowers, Christopher R.; McCall, Chad M.; Neff, Jadee; McKinney, Matthew S.; Fedoriw, Yuri; Powers, Eric; Montgomery, Nathan D.; Bogusz, Agata M.; Stafford Hintz, Andrea; Kovach, Alexandra E.; Reddy, Nishitha; Thompson Arildsen, Mary Ann; Mason, Emily F.; Juskevicius, Ridas; Choi, William; Au-Yeung, Rex; Tse, Eric; Sarno, Vincent; Chadburn, Amy; Lopez, Rafael; Chapman, Jennifer R.; Behdad, Amir; Goldschmidt, Neta; Goodlad, John; Burton, Cathy; Pillai, Raju; Louissaint, Abner; Soliman, Dina Sameh; Panea, Razvan; Dave, Tushar; Xiong, Barbara; Smith, Eileen; Dave, Sandeep.

In: Blood, Vol. 134, No. 1, 13.11.2019.

Research output: Contribution to journalArticle

Li, X, Kositsky, R, Reddy, A, Love, C, Naresh, K, Koff, JL, Nystrand, I, Leppä, S, Pasanen, A, Karjalainen-Lindsberg, ML, Dunkel, J, Kovanen, P, Qin, Q, Bhagat, G, Leeman-Neill, RJ, Goswami, RS, Wildeman, S, Delabie, J, Burack, R, Evans, AG, Amador, C, Yuan, J, Qureishi, HN, Li, S, Xu, J, Yin, CC, Gang, AO, Norgaard, PH, Pedersen, M, Chan, JY, Cheah, DMZ, Ong, SY, Cheng, CL, Lee, L, Paulua, F, Ondrejka, SL, Hsi, ED, Czader, M, Wang, L, Landis, A, Churnetski, MC, Jaye, DL, Flowers, CR, McCall, CM, Neff, J, McKinney, MS, Fedoriw, Y, Powers, E, Montgomery, ND, Bogusz, AM, Stafford Hintz, A, Kovach, AE, Reddy, N, Thompson Arildsen, MA, Mason, EF, Juskevicius, R, Choi, W, Au-Yeung, R, Tse, E, Sarno, V, Chadburn, A, Lopez, R, Chapman, JR, Behdad, A, Goldschmidt, N, Goodlad, J, Burton, C, Pillai, R, Louissaint, A, Soliman, DS, Panea, R, Dave, T, Xiong, B, Smith, E & Dave, S 2019, 'Whole Exome and Transcriptome Sequencing in 1042 Cases Reveals Distinct Clinically Relevant Genetic Subgroups of Follicular Lymphoma', Blood, vol. 134, no. 1. https://doi.org/10.1182/blood-2019-130255
Li, Xiang ; Kositsky, Rachel ; Reddy, Anupama ; Love, Cassandra ; Naresh, Kikkeri ; Koff, Jean L. ; Nystrand, Ilja ; Leppä, Sirpa ; Pasanen, Annika ; Karjalainen-Lindsberg, Marja Liisa ; Dunkel, Johannes ; Kovanen, Panu ; Qin, Qiu ; Bhagat, Govind ; Leeman-Neill, Rebecca J. ; Goswami, Rashmi S. ; Wildeman, Sarah ; Delabie, Jan ; Burack, Richard ; Evans, Andrew G. ; Amador, Catalina ; Yuan, Ji ; Qureishi, Hina Naushad ; Li, Shaoying ; Xu, Jie ; Yin, C. Cameron ; Gang, Anne Ortved ; Norgaard, Peter H. ; Pedersen, Mette ; Chan, Jason Yongsheng ; Cheah, Daryl Ming Zhe ; Ong, Shin Yeu ; Cheng, Chee Leong ; Lee, Lianne ; Paulua, Felik ; Ondrejka, Sarah L. ; Hsi, Eric D. ; Czader, Magdalena ; Wang, Lin ; Landis, Amber ; Churnetski, Michael C. ; Jaye, David L. ; Flowers, Christopher R. ; McCall, Chad M. ; Neff, Jadee ; McKinney, Matthew S. ; Fedoriw, Yuri ; Powers, Eric ; Montgomery, Nathan D. ; Bogusz, Agata M. ; Stafford Hintz, Andrea ; Kovach, Alexandra E. ; Reddy, Nishitha ; Thompson Arildsen, Mary Ann ; Mason, Emily F. ; Juskevicius, Ridas ; Choi, William ; Au-Yeung, Rex ; Tse, Eric ; Sarno, Vincent ; Chadburn, Amy ; Lopez, Rafael ; Chapman, Jennifer R. ; Behdad, Amir ; Goldschmidt, Neta ; Goodlad, John ; Burton, Cathy ; Pillai, Raju ; Louissaint, Abner ; Soliman, Dina Sameh ; Panea, Razvan ; Dave, Tushar ; Xiong, Barbara ; Smith, Eileen ; Dave, Sandeep. / Whole Exome and Transcriptome Sequencing in 1042 Cases Reveals Distinct Clinically Relevant Genetic Subgroups of Follicular Lymphoma. In: Blood. 2019 ; Vol. 134, No. 1.
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title = "Whole Exome and Transcriptome Sequencing in 1042 Cases Reveals Distinct Clinically Relevant Genetic Subgroups of Follicular Lymphoma",
abstract = "DISCLOSURES: Koff: Burroughs Wellcome Fund: Research Funding; V Foundation: Research Funding; Lymphoma Research Foundation: Research Funding; American Association for Cancer Research: Research Funding. Lepp{\"a}:Roche: Honoraria, Research Funding; Takeda: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Bayer: Research Funding; Celgene: Membership on an entity's Board of Directors or advisory committees, Research Funding; Janssen-Cilag: Research Funding; Novartis: Membership on an entity's Board of Directors or advisory committees. Gang:ROCHE: Membership on an entity's Board of Directors or advisory committees; Novartis: Membership on an entity's Board of Directors or advisory committees. Hsi:Abbvie: Research Funding; Eli Lilly: Research Funding; Cleveland Clinic&Abbvie Biotherapeutics Inc: Patents & Royalties: US8,603,477 B2; Jazz: Consultancy. Flowers:AbbVie: Consultancy, Research Funding; Denovo Biopharma: Consultancy; BeiGene: Consultancy, Research Funding; Burroughs Wellcome Fund: Research Funding; Eastern Cooperative Oncology Group: Research Funding; National Cancer Institute: Research Funding; V Foundation: Research Funding; Optimum Rx: Consultancy; Millenium/Takeda: Research Funding; TG Therapeutics: Research Funding; Gilead: Consultancy, Research Funding; Celgene: Consultancy, Research Funding; Karyopharm: Consultancy; AstraZeneca: Consultancy; Pharmacyclics/Janssen: Consultancy, Research Funding; Spectrum: Consultancy; Bayer: Consultancy; Acerta: Research Funding; Genentech, Inc./F. Hoffmann-La Roche Ltd: Consultancy, Research Funding. Neff:Enzyvant: Consultancy; EUSA Pharma: Honoraria, Membership on an entity's Board of Directors or advisory committees. Fedoriw:Alexion Pharmaceuticals: Other: Consultant and Speaker. Reddy:Genentech: Research Funding; BMS: Consultancy, Research Funding; Celgene: Consultancy; KITE Pharma: Consultancy; Abbvie: Consultancy. Mason:Sysmex: Honoraria. Behdad:Loxo-Bayer: Membership on an entity's Board of Directors or advisory committees; Thermo Fisher: Membership on an entity's Board of Directors or advisory committees; Pfizer: Other: Speaker. Burton:Bristol-Myers Squibb: Honoraria, Membership on an entity's Board of Directors or advisory committees; Roche: Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: Travel; Celgene: Membership on an entity's Board of Directors or advisory committees; Takeda: Honoraria, Membership on an entity's Board of Directors or advisory committees. Dave:Data Driven Bioscience: Equity Ownership.",
author = "Xiang Li and Rachel Kositsky and Anupama Reddy and Cassandra Love and Kikkeri Naresh and Koff, {Jean L.} and Ilja Nystrand and Sirpa Lepp{\"a} and Annika Pasanen and Karjalainen-Lindsberg, {Marja Liisa} and Johannes Dunkel and Panu Kovanen and Qiu Qin and Govind Bhagat and Leeman-Neill, {Rebecca J.} and Goswami, {Rashmi S.} and Sarah Wildeman and Jan Delabie and Richard Burack and Evans, {Andrew G.} and Catalina Amador and Ji Yuan and Qureishi, {Hina Naushad} and Shaoying Li and Jie Xu and Yin, {C. Cameron} and Gang, {Anne Ortved} and Norgaard, {Peter H.} and Mette Pedersen and Chan, {Jason Yongsheng} and Cheah, {Daryl Ming Zhe} and Ong, {Shin Yeu} and Cheng, {Chee Leong} and Lianne Lee and Felik Paulua and Ondrejka, {Sarah L.} and Hsi, {Eric D.} and Magdalena Czader and Lin Wang and Amber Landis and Churnetski, {Michael C.} and Jaye, {David L.} and Flowers, {Christopher R.} and McCall, {Chad M.} and Jadee Neff and McKinney, {Matthew S.} and Yuri Fedoriw and Eric Powers and Montgomery, {Nathan D.} and Bogusz, {Agata M.} and {Stafford Hintz}, Andrea and Kovach, {Alexandra E.} and Nishitha Reddy and {Thompson Arildsen}, {Mary Ann} and Mason, {Emily F.} and Ridas Juskevicius and William Choi and Rex Au-Yeung and Eric Tse and Vincent Sarno and Amy Chadburn and Rafael Lopez and Chapman, {Jennifer R.} and Amir Behdad and Neta Goldschmidt and John Goodlad and Cathy Burton and Raju Pillai and Abner Louissaint and Soliman, {Dina Sameh} and Razvan Panea and Tushar Dave and Barbara Xiong and Eileen Smith and Sandeep Dave",
year = "2019",
month = "11",
day = "13",
doi = "10.1182/blood-2019-130255",
language = "English (US)",
volume = "134",
journal = "Blood",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "1",

}

TY - JOUR

T1 - Whole Exome and Transcriptome Sequencing in 1042 Cases Reveals Distinct Clinically Relevant Genetic Subgroups of Follicular Lymphoma

AU - Li, Xiang

AU - Kositsky, Rachel

AU - Reddy, Anupama

AU - Love, Cassandra

AU - Naresh, Kikkeri

AU - Koff, Jean L.

AU - Nystrand, Ilja

AU - Leppä, Sirpa

AU - Pasanen, Annika

AU - Karjalainen-Lindsberg, Marja Liisa

AU - Dunkel, Johannes

AU - Kovanen, Panu

AU - Qin, Qiu

AU - Bhagat, Govind

AU - Leeman-Neill, Rebecca J.

AU - Goswami, Rashmi S.

AU - Wildeman, Sarah

AU - Delabie, Jan

AU - Burack, Richard

AU - Evans, Andrew G.

AU - Amador, Catalina

AU - Yuan, Ji

AU - Qureishi, Hina Naushad

AU - Li, Shaoying

AU - Xu, Jie

AU - Yin, C. Cameron

AU - Gang, Anne Ortved

AU - Norgaard, Peter H.

AU - Pedersen, Mette

AU - Chan, Jason Yongsheng

AU - Cheah, Daryl Ming Zhe

AU - Ong, Shin Yeu

AU - Cheng, Chee Leong

AU - Lee, Lianne

AU - Paulua, Felik

AU - Ondrejka, Sarah L.

AU - Hsi, Eric D.

AU - Czader, Magdalena

AU - Wang, Lin

AU - Landis, Amber

AU - Churnetski, Michael C.

AU - Jaye, David L.

AU - Flowers, Christopher R.

AU - McCall, Chad M.

AU - Neff, Jadee

AU - McKinney, Matthew S.

AU - Fedoriw, Yuri

AU - Powers, Eric

AU - Montgomery, Nathan D.

AU - Bogusz, Agata M.

AU - Stafford Hintz, Andrea

AU - Kovach, Alexandra E.

AU - Reddy, Nishitha

AU - Thompson Arildsen, Mary Ann

AU - Mason, Emily F.

AU - Juskevicius, Ridas

AU - Choi, William

AU - Au-Yeung, Rex

AU - Tse, Eric

AU - Sarno, Vincent

AU - Chadburn, Amy

AU - Lopez, Rafael

AU - Chapman, Jennifer R.

AU - Behdad, Amir

AU - Goldschmidt, Neta

AU - Goodlad, John

AU - Burton, Cathy

AU - Pillai, Raju

AU - Louissaint, Abner

AU - Soliman, Dina Sameh

AU - Panea, Razvan

AU - Dave, Tushar

AU - Xiong, Barbara

AU - Smith, Eileen

AU - Dave, Sandeep

PY - 2019/11/13

Y1 - 2019/11/13

N2 - DISCLOSURES: Koff: Burroughs Wellcome Fund: Research Funding; V Foundation: Research Funding; Lymphoma Research Foundation: Research Funding; American Association for Cancer Research: Research Funding. Leppä:Roche: Honoraria, Research Funding; Takeda: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Bayer: Research Funding; Celgene: Membership on an entity's Board of Directors or advisory committees, Research Funding; Janssen-Cilag: Research Funding; Novartis: Membership on an entity's Board of Directors or advisory committees. Gang:ROCHE: Membership on an entity's Board of Directors or advisory committees; Novartis: Membership on an entity's Board of Directors or advisory committees. Hsi:Abbvie: Research Funding; Eli Lilly: Research Funding; Cleveland Clinic&Abbvie Biotherapeutics Inc: Patents & Royalties: US8,603,477 B2; Jazz: Consultancy. Flowers:AbbVie: Consultancy, Research Funding; Denovo Biopharma: Consultancy; BeiGene: Consultancy, Research Funding; Burroughs Wellcome Fund: Research Funding; Eastern Cooperative Oncology Group: Research Funding; National Cancer Institute: Research Funding; V Foundation: Research Funding; Optimum Rx: Consultancy; Millenium/Takeda: Research Funding; TG Therapeutics: Research Funding; Gilead: Consultancy, Research Funding; Celgene: Consultancy, Research Funding; Karyopharm: Consultancy; AstraZeneca: Consultancy; Pharmacyclics/Janssen: Consultancy, Research Funding; Spectrum: Consultancy; Bayer: Consultancy; Acerta: Research Funding; Genentech, Inc./F. Hoffmann-La Roche Ltd: Consultancy, Research Funding. Neff:Enzyvant: Consultancy; EUSA Pharma: Honoraria, Membership on an entity's Board of Directors or advisory committees. Fedoriw:Alexion Pharmaceuticals: Other: Consultant and Speaker. Reddy:Genentech: Research Funding; BMS: Consultancy, Research Funding; Celgene: Consultancy; KITE Pharma: Consultancy; Abbvie: Consultancy. Mason:Sysmex: Honoraria. Behdad:Loxo-Bayer: Membership on an entity's Board of Directors or advisory committees; Thermo Fisher: Membership on an entity's Board of Directors or advisory committees; Pfizer: Other: Speaker. Burton:Bristol-Myers Squibb: Honoraria, Membership on an entity's Board of Directors or advisory committees; Roche: Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: Travel; Celgene: Membership on an entity's Board of Directors or advisory committees; Takeda: Honoraria, Membership on an entity's Board of Directors or advisory committees. Dave:Data Driven Bioscience: Equity Ownership.

AB - DISCLOSURES: Koff: Burroughs Wellcome Fund: Research Funding; V Foundation: Research Funding; Lymphoma Research Foundation: Research Funding; American Association for Cancer Research: Research Funding. Leppä:Roche: Honoraria, Research Funding; Takeda: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Bayer: Research Funding; Celgene: Membership on an entity's Board of Directors or advisory committees, Research Funding; Janssen-Cilag: Research Funding; Novartis: Membership on an entity's Board of Directors or advisory committees. Gang:ROCHE: Membership on an entity's Board of Directors or advisory committees; Novartis: Membership on an entity's Board of Directors or advisory committees. Hsi:Abbvie: Research Funding; Eli Lilly: Research Funding; Cleveland Clinic&Abbvie Biotherapeutics Inc: Patents & Royalties: US8,603,477 B2; Jazz: Consultancy. Flowers:AbbVie: Consultancy, Research Funding; Denovo Biopharma: Consultancy; BeiGene: Consultancy, Research Funding; Burroughs Wellcome Fund: Research Funding; Eastern Cooperative Oncology Group: Research Funding; National Cancer Institute: Research Funding; V Foundation: Research Funding; Optimum Rx: Consultancy; Millenium/Takeda: Research Funding; TG Therapeutics: Research Funding; Gilead: Consultancy, Research Funding; Celgene: Consultancy, Research Funding; Karyopharm: Consultancy; AstraZeneca: Consultancy; Pharmacyclics/Janssen: Consultancy, Research Funding; Spectrum: Consultancy; Bayer: Consultancy; Acerta: Research Funding; Genentech, Inc./F. Hoffmann-La Roche Ltd: Consultancy, Research Funding. Neff:Enzyvant: Consultancy; EUSA Pharma: Honoraria, Membership on an entity's Board of Directors or advisory committees. Fedoriw:Alexion Pharmaceuticals: Other: Consultant and Speaker. Reddy:Genentech: Research Funding; BMS: Consultancy, Research Funding; Celgene: Consultancy; KITE Pharma: Consultancy; Abbvie: Consultancy. Mason:Sysmex: Honoraria. Behdad:Loxo-Bayer: Membership on an entity's Board of Directors or advisory committees; Thermo Fisher: Membership on an entity's Board of Directors or advisory committees; Pfizer: Other: Speaker. Burton:Bristol-Myers Squibb: Honoraria, Membership on an entity's Board of Directors or advisory committees; Roche: Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: Travel; Celgene: Membership on an entity's Board of Directors or advisory committees; Takeda: Honoraria, Membership on an entity's Board of Directors or advisory committees. Dave:Data Driven Bioscience: Equity Ownership.

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U2 - 10.1182/blood-2019-130255

DO - 10.1182/blood-2019-130255

M3 - Article

C2 - 31723982

AN - SCOPUS:85074960934

VL - 134

JO - Blood

JF - Blood

SN - 0006-4971

IS - 1

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