Why can't the immune system control HIV-1? Defining HIV-1-specific CD4 + T cell immunity in order to develop strategies to enhance viral immunity

Mario A. Ostrowski, Qigui Yu, Feng Yun Yue, Jun Liu, Brad Jones, Xiao X. Gu, Mona Loutfy, Colin M. Kovacs, Roberta Halpenny

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Globally, at least 60 million people have been infected with the human immunodeficiency virus type 1 (HIV-1), the majority of whom will develop the acquired immunodeficiency syndrome (AIDS) leading to tremendous morbidity and the mortality. Understanding the immunopathogenesis of AIDS and the immune correlates of viral protection are necessary to develop effective vaccines and immunotherapies. A major focus of our laboratory has been to understand the CD4+ T cell immune response directed against HIV- 1, and to determine mechanisms of T cell dysfunction that lead to viral escape. In addition, we are interested in evaluating the TNF-TNFR family members as potential molecular adjuvants that could be incorporated into vaccines which could be used to further boost T cell immunogenicity in healthy or HIV-1-infected individuals, as many of these molecules have been shown to replace the functions of CD4 + T cell help.

Original languageEnglish (US)
Pages (from-to)89-101
Number of pages13
JournalImmunologic Research
Volume35
Issue number1-2
DOIs
StatePublished - May 2006
Externally publishedYes

Keywords

  • Apoptosis
  • CD4 T cell maturation
  • Dendritic cells
  • HIV-1
  • TNF superfamily

ASJC Scopus subject areas

  • Immunology

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