Widespread white matter and conduction defects in PSEN1-related spastic paraparesis

Steffan K. Soosman, Nelly Joseph-Mathurin, Meredith N. Braskie, Yvette M. Bordelon, David Wharton, Maria Casado, Giovanni Coppola, Holly McCallum, Marc Nuwer, Pedro Coutin-Churchman, Liana G. Apostolova, Tammie Benzinger, John M. Ringman

Research output: Contribution to journalArticle

Abstract

The mechanisms underlying presenilin 1 (PSEN1) mutation–associated spastic paraparesis (SP) are not clear. We compared diffusion and volumetric magnetic resonance measures between 3 persons with SP associated with the A431E mutation and 7 symptomatic persons with PSEN1 mutations without SP matched for symptom duration. We performed amyloid imaging and central motor and somatosensory conduction studies in 1 subject with SP. We found decreases in fractional anisotropy and increases in mean diffusivity in widespread white-matter areas including the corpus callosum, occipital, parietal, and frontal lobes in PSEN1 mutation carriers with SP. Volumetric measures were not different, and amyloid imaging showed low signal in sensorimotor cortex and other areas in a single subject with SP. Electrophysiological studies demonstrated both slowed motor and sensory conduction in the lower extremities in this same subject. Our results suggest that SP in carriers of the A431E PSEN1 mutation is a manifestation of widespread white-matter abnormalities not confined to the corticospinal tract that is at most indirectly related to the mutation's effect on amyloid precursor protein processing and amyloid deposition.

Original languageEnglish (US)
Pages (from-to)201-209
Number of pages9
JournalNeurobiology of Aging
Volume47
DOIs
StatePublished - Nov 1 2016

Fingerprint

Spastic Paraparesis
Presenilin-1
Mutation
Amyloid
Occipital Lobe
Parietal Lobe
Pyramidal Tracts
Amyloid beta-Protein Precursor
Corpus Callosum
Anisotropy
Frontal Lobe
White Matter
Lower Extremity
Magnetic Resonance Spectroscopy

Keywords

  • Diffusion tensor imaging
  • Electrophysiology
  • PSEN1
  • spastic paraparesis
  • White matter

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Soosman, S. K., Joseph-Mathurin, N., Braskie, M. N., Bordelon, Y. M., Wharton, D., Casado, M., ... Ringman, J. M. (2016). Widespread white matter and conduction defects in PSEN1-related spastic paraparesis. Neurobiology of Aging, 47, 201-209. https://doi.org/10.1016/j.neurobiolaging.2016.07.030

Widespread white matter and conduction defects in PSEN1-related spastic paraparesis. / Soosman, Steffan K.; Joseph-Mathurin, Nelly; Braskie, Meredith N.; Bordelon, Yvette M.; Wharton, David; Casado, Maria; Coppola, Giovanni; McCallum, Holly; Nuwer, Marc; Coutin-Churchman, Pedro; Apostolova, Liana G.; Benzinger, Tammie; Ringman, John M.

In: Neurobiology of Aging, Vol. 47, 01.11.2016, p. 201-209.

Research output: Contribution to journalArticle

Soosman, SK, Joseph-Mathurin, N, Braskie, MN, Bordelon, YM, Wharton, D, Casado, M, Coppola, G, McCallum, H, Nuwer, M, Coutin-Churchman, P, Apostolova, LG, Benzinger, T & Ringman, JM 2016, 'Widespread white matter and conduction defects in PSEN1-related spastic paraparesis', Neurobiology of Aging, vol. 47, pp. 201-209. https://doi.org/10.1016/j.neurobiolaging.2016.07.030
Soosman SK, Joseph-Mathurin N, Braskie MN, Bordelon YM, Wharton D, Casado M et al. Widespread white matter and conduction defects in PSEN1-related spastic paraparesis. Neurobiology of Aging. 2016 Nov 1;47:201-209. https://doi.org/10.1016/j.neurobiolaging.2016.07.030
Soosman, Steffan K. ; Joseph-Mathurin, Nelly ; Braskie, Meredith N. ; Bordelon, Yvette M. ; Wharton, David ; Casado, Maria ; Coppola, Giovanni ; McCallum, Holly ; Nuwer, Marc ; Coutin-Churchman, Pedro ; Apostolova, Liana G. ; Benzinger, Tammie ; Ringman, John M. / Widespread white matter and conduction defects in PSEN1-related spastic paraparesis. In: Neurobiology of Aging. 2016 ; Vol. 47. pp. 201-209.
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