Wnt signaling in lactation: A balancing act

Jenifer Prosperi, Kathleen H. Goss

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The mammary gland is unique in that most of its development and dynamic morphogenesis occurs postnatally in response to changes in the hormonal milieu. Multiple components of the Wnt/β-catenin signaling pathway have been implicated in mouse mammary gland development. It is clear that the Wnt proteins themselves are important regulators of numerous stages throughout postnatal mammary gland development. Mouse models have been developed to analyze whether β-catenin stabilization, expression of pathway components, or expression of Wnt/-βcatenin target genes is sufficient to disrupt mammary gland development and lactation. In addition to the role of β-catenin in the Wnt signaling pathway, it is also a major component of the adherens junctions and as such, has a role in maintaining epithelial integrity, which is essential for lactation.Multiple components of the Wnt pathway are known to have cross-regulation with other signaling pathways involved in the lactogenic phenotype. Furthermore, investigation into the regulation of Wnt pathway components has demonstrated that hormones, such as progesterone, can regulate components of the Wnt pathway. Through various mouse models of mammary gland development, it has become clear that the Wnt/β-catenin signaling pathway is a critical regulator of normal mammary gland development. Interestingly, the specific roles of Wnt pathway regulators and components in lactation have given us insight to alterations that occur in breast tumor development.

Original languageEnglish
Title of host publicationLactation: Natural Processes, Physiological Responses and Role in Maternity
PublisherNova Science Publishers, Inc.
Pages121-134
Number of pages14
ISBN (Print)9781622572434
StatePublished - Sep 2012

Fingerprint

Wnt Signaling Pathway
Lactation
Catenins
Human Mammary Glands
Wnt Proteins
Adherens Junctions
Morphogenesis
Progesterone
Hormones
Breast Neoplasms
Phenotype
Genes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Prosperi, J., & Goss, K. H. (2012). Wnt signaling in lactation: A balancing act. In Lactation: Natural Processes, Physiological Responses and Role in Maternity (pp. 121-134). Nova Science Publishers, Inc..

Wnt signaling in lactation : A balancing act. / Prosperi, Jenifer; Goss, Kathleen H.

Lactation: Natural Processes, Physiological Responses and Role in Maternity. Nova Science Publishers, Inc., 2012. p. 121-134.

Research output: Chapter in Book/Report/Conference proceedingChapter

Prosperi, J & Goss, KH 2012, Wnt signaling in lactation: A balancing act. in Lactation: Natural Processes, Physiological Responses and Role in Maternity. Nova Science Publishers, Inc., pp. 121-134.
Prosperi J, Goss KH. Wnt signaling in lactation: A balancing act. In Lactation: Natural Processes, Physiological Responses and Role in Maternity. Nova Science Publishers, Inc. 2012. p. 121-134
Prosperi, Jenifer ; Goss, Kathleen H. / Wnt signaling in lactation : A balancing act. Lactation: Natural Processes, Physiological Responses and Role in Maternity. Nova Science Publishers, Inc., 2012. pp. 121-134
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