Women with bipolar disorder

Findings from the NIMH genetics initiative sample

Mary C. Blehar, J. Raymond DePaulo, Elliot S. Gershon, Theodore Reich, Sylvia G. Simpson, John Nurnberger

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

Bipolar I (BPI) mood disorder is a severe recurrent mental illness with a population prevalence of 1 percent. Evidence is strong for genetic risk factors in onset. However, unlike unipolar mood disorders, in which women outnumber men by 2 to 1, for BPI disorder, the male:female ratio is equal. Perhaps for this reason, relatively little research has examined gender- related risks in BPI course. This article presents data from 186 BPI women and 141 BPI men ascertained as part of the NIMH Genetics Initiative, a multisite collaborative molecular genetic study. Subjects were interviewed using the Diagnostic Interview for Genetic Studies (DIGS). DIGS items included a medical history, and for women, questions concerning psychiatric disorders in relation to childbearing, the menstrual cycle, and menopause. Almost half of BPI women who had been pregnant reported having experienced severe emotional disturbances in relation to childbearing, with close to one- third reporting episode onset during pregnancy. Two-thirds of BPI women reported frequent premenstrual mood disturbances and almost 20 percent of ppostmenopausal BPI women reported severe emotional disturbances during the menopausal transition. More BPI women than men reported thyroid disorder and migraine headaches. Findings are discussed in relation to gender differences in population and other clinical samples, and in terms of their implications for the development of new treatments and preventive interventions.

Original languageEnglish
Pages (from-to)239-243
Number of pages5
JournalPsychopharmacology Bulletin
Volume34
Issue number3
StatePublished - 1998

Fingerprint

National Institute of Mental Health (U.S.)
Bipolar Disorder
Affective Symptoms
Mood Disorders
Interviews
Interpersonal Relations
Menstrual Cycle
Menopause
Migraine Disorders
Population
Psychiatry
Molecular Biology
Thyroid Gland
Pregnancy
Research

Keywords

  • Bipolar disorder
  • Family studies
  • Gender differences
  • Genetics
  • Menopause
  • Postpartum
  • Premenstrual exacerbation

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

Cite this

Blehar, M. C., DePaulo, J. R., Gershon, E. S., Reich, T., Simpson, S. G., & Nurnberger, J. (1998). Women with bipolar disorder: Findings from the NIMH genetics initiative sample. Psychopharmacology Bulletin, 34(3), 239-243.

Women with bipolar disorder : Findings from the NIMH genetics initiative sample. / Blehar, Mary C.; DePaulo, J. Raymond; Gershon, Elliot S.; Reich, Theodore; Simpson, Sylvia G.; Nurnberger, John.

In: Psychopharmacology Bulletin, Vol. 34, No. 3, 1998, p. 239-243.

Research output: Contribution to journalArticle

Blehar, MC, DePaulo, JR, Gershon, ES, Reich, T, Simpson, SG & Nurnberger, J 1998, 'Women with bipolar disorder: Findings from the NIMH genetics initiative sample', Psychopharmacology Bulletin, vol. 34, no. 3, pp. 239-243.
Blehar, Mary C. ; DePaulo, J. Raymond ; Gershon, Elliot S. ; Reich, Theodore ; Simpson, Sylvia G. ; Nurnberger, John. / Women with bipolar disorder : Findings from the NIMH genetics initiative sample. In: Psychopharmacology Bulletin. 1998 ; Vol. 34, No. 3. pp. 239-243.
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