Working hypothesis to redefine endothelial progenitor cells

Research output: Contribution to journalArticle

233 Citations (Scopus)

Abstract

Since 1997, postnatal vasculogenesis has been purported to be an important mechanism for neoangiogenesis via bone marrow (BM)-derived circulating endothelial progenitor cells (EPCs). Based on this paradigm, EPCs have been extensively studied as biomarkers to assess severity of cardiovascular disease and as a cell-based therapy for several human cardiovascular disorders. In the majority of studies to date, EPCs were identified and enumerated by two primary methodologies; EPCs were obtained and quantified following in vitro cell culture, or EPCs were identified and enumerated by flow cytometry. Both methods have proven controversial. This review will attempt to outline the definition of EPCs from some of the most widely cited published reports in an effort to provide a framework for understanding subsequent studies in this rapidly evolving field. We will focus this review on studies that used cell culture techniques to define EPCs.

Original languageEnglish
Pages (from-to)1141-1149
Number of pages9
JournalLeukemia
Volume21
Issue number6
DOIs
StatePublished - Jun 2007

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Cell Culture Techniques
Cell- and Tissue-Based Therapy
Endothelial Progenitor Cells
Flow Cytometry
Cardiovascular Diseases
Biomarkers
Bone Marrow
In Vitro Techniques

ASJC Scopus subject areas

  • Hematology
  • Cancer Research

Cite this

Working hypothesis to redefine endothelial progenitor cells. / Prater, D. N.; Case, Jamie; Ingram, David; Yoder, Mervin.

In: Leukemia, Vol. 21, No. 6, 06.2007, p. 1141-1149.

Research output: Contribution to journalArticle

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