Wounding with a microneedling device corrects the inappropriate ultraviolet B radiation response in geriatric skin

Jeffrey B. Travers, Michael G. Kemp, Nathan M. Weir, Elizabeth Cates, Abdulrahman M. Alkawar, Avinash S. Mahajan, Dan F. Spandau

Research output: Contribution to journalArticle

Abstract

Non-melanoma skin cancer primarily affects geriatric patients as evidenced by the fact that only 20% of these cancers are diagnosed in patients under the age of 60 years. Of importance, geriatric skin responds to procarcinogenic ultraviolet B radiation (UVB) in a manner that permits the establishment of tumor cells. Recent studies have indicated that wounding of geriatric skin with fractionated resurfacing lasers and dermabrasion upregulates fibroblast production of insulin-like growth factor-1 (IGF-1) and normalizes the procarcinogenic acute UVB response consisting of basal keratinocytes proliferating while still harboring unrepaired DNA damage. The present studies tested the ability of wounding with a commercially available microneedling device to upregulate IGF-1 levels and normalize the geriatric UVB response. Geriatric volunteers were treated with a microneedling device on buttock skin and 3 months later the IGF-1 levels and UVB responses tested in wounded vs control skin. Wounding via microneedling upregulated IGF-1 and resulted in lower levels of basal keratinocytes proliferating with unrepaired DNA damage. The ability of microneedling to protect against the formation of UVB-damaged proliferating keratinocytes indicates the potential of this wounding modality to reduce aging-associated non-melanoma skin cancer.

Original languageEnglish (US)
JournalArchives of Dermatological Research
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Geriatrics
Somatomedins
Radiation
Equipment and Supplies
Skin
Keratinocytes
Skin Neoplasms
DNA Damage
Up-Regulation
Dermabrasion
Buttocks
Volunteers
Neoplasms
Lasers
Fibroblasts

Keywords

  • Insulin-like growth factor-1
  • Ultraviolet B radiation
  • Wounding

ASJC Scopus subject areas

  • Dermatology

Cite this

Wounding with a microneedling device corrects the inappropriate ultraviolet B radiation response in geriatric skin. / Travers, Jeffrey B.; Kemp, Michael G.; Weir, Nathan M.; Cates, Elizabeth; Alkawar, Abdulrahman M.; Mahajan, Avinash S.; Spandau, Dan F.

In: Archives of Dermatological Research, 01.01.2019.

Research output: Contribution to journalArticle

@article{f310a407cb4e4c4ea852332d14d7abcf,
title = "Wounding with a microneedling device corrects the inappropriate ultraviolet B radiation response in geriatric skin",
abstract = "Non-melanoma skin cancer primarily affects geriatric patients as evidenced by the fact that only 20{\%} of these cancers are diagnosed in patients under the age of 60 years. Of importance, geriatric skin responds to procarcinogenic ultraviolet B radiation (UVB) in a manner that permits the establishment of tumor cells. Recent studies have indicated that wounding of geriatric skin with fractionated resurfacing lasers and dermabrasion upregulates fibroblast production of insulin-like growth factor-1 (IGF-1) and normalizes the procarcinogenic acute UVB response consisting of basal keratinocytes proliferating while still harboring unrepaired DNA damage. The present studies tested the ability of wounding with a commercially available microneedling device to upregulate IGF-1 levels and normalize the geriatric UVB response. Geriatric volunteers were treated with a microneedling device on buttock skin and 3 months later the IGF-1 levels and UVB responses tested in wounded vs control skin. Wounding via microneedling upregulated IGF-1 and resulted in lower levels of basal keratinocytes proliferating with unrepaired DNA damage. The ability of microneedling to protect against the formation of UVB-damaged proliferating keratinocytes indicates the potential of this wounding modality to reduce aging-associated non-melanoma skin cancer.",
keywords = "Insulin-like growth factor-1, Ultraviolet B radiation, Wounding",
author = "Travers, {Jeffrey B.} and Kemp, {Michael G.} and Weir, {Nathan M.} and Elizabeth Cates and Alkawar, {Abdulrahman M.} and Mahajan, {Avinash S.} and Spandau, {Dan F.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1007/s00403-019-02001-z",
language = "English (US)",
journal = "Archives of Dermatological Research",
issn = "0340-3696",
publisher = "Springer Verlag",

}

TY - JOUR

T1 - Wounding with a microneedling device corrects the inappropriate ultraviolet B radiation response in geriatric skin

AU - Travers, Jeffrey B.

AU - Kemp, Michael G.

AU - Weir, Nathan M.

AU - Cates, Elizabeth

AU - Alkawar, Abdulrahman M.

AU - Mahajan, Avinash S.

AU - Spandau, Dan F.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Non-melanoma skin cancer primarily affects geriatric patients as evidenced by the fact that only 20% of these cancers are diagnosed in patients under the age of 60 years. Of importance, geriatric skin responds to procarcinogenic ultraviolet B radiation (UVB) in a manner that permits the establishment of tumor cells. Recent studies have indicated that wounding of geriatric skin with fractionated resurfacing lasers and dermabrasion upregulates fibroblast production of insulin-like growth factor-1 (IGF-1) and normalizes the procarcinogenic acute UVB response consisting of basal keratinocytes proliferating while still harboring unrepaired DNA damage. The present studies tested the ability of wounding with a commercially available microneedling device to upregulate IGF-1 levels and normalize the geriatric UVB response. Geriatric volunteers were treated with a microneedling device on buttock skin and 3 months later the IGF-1 levels and UVB responses tested in wounded vs control skin. Wounding via microneedling upregulated IGF-1 and resulted in lower levels of basal keratinocytes proliferating with unrepaired DNA damage. The ability of microneedling to protect against the formation of UVB-damaged proliferating keratinocytes indicates the potential of this wounding modality to reduce aging-associated non-melanoma skin cancer.

AB - Non-melanoma skin cancer primarily affects geriatric patients as evidenced by the fact that only 20% of these cancers are diagnosed in patients under the age of 60 years. Of importance, geriatric skin responds to procarcinogenic ultraviolet B radiation (UVB) in a manner that permits the establishment of tumor cells. Recent studies have indicated that wounding of geriatric skin with fractionated resurfacing lasers and dermabrasion upregulates fibroblast production of insulin-like growth factor-1 (IGF-1) and normalizes the procarcinogenic acute UVB response consisting of basal keratinocytes proliferating while still harboring unrepaired DNA damage. The present studies tested the ability of wounding with a commercially available microneedling device to upregulate IGF-1 levels and normalize the geriatric UVB response. Geriatric volunteers were treated with a microneedling device on buttock skin and 3 months later the IGF-1 levels and UVB responses tested in wounded vs control skin. Wounding via microneedling upregulated IGF-1 and resulted in lower levels of basal keratinocytes proliferating with unrepaired DNA damage. The ability of microneedling to protect against the formation of UVB-damaged proliferating keratinocytes indicates the potential of this wounding modality to reduce aging-associated non-melanoma skin cancer.

KW - Insulin-like growth factor-1

KW - Ultraviolet B radiation

KW - Wounding

UR - http://www.scopus.com/inward/record.url?scp=85074645229&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85074645229&partnerID=8YFLogxK

U2 - 10.1007/s00403-019-02001-z

DO - 10.1007/s00403-019-02001-z

M3 - Article

C2 - 31659432

AN - SCOPUS:85074645229

JO - Archives of Dermatological Research

JF - Archives of Dermatological Research

SN - 0340-3696

ER -