X-linked Inheritance of Epidermodysplasia Verruciformis: Genetic and Virologic Studies of a Kindred

Elliot Androphy, Israel Dvoretzky, Douglas R. Lowy

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84 Citations (Scopus)

Abstract

We describe a family with typical epidermodysplasia verruciformis (EV) in which only male members are affected. Whereas none of the index patient's ten children have EV, four of eight grandsons born to his daughters have inherited the disorder. All are infected with human papillomavirus (HPV) 3 and HPV 8. The inheritance in this kindred most likely results from an X-linked recessive genetic defect. Since other kindreds have been described with autosomal inheritance, this novel inheritance pattern suggests that the persistent high clinical susceptibility to HPV infection characteristic of EV may result from defects in either of at least two different genetic loci, one of which may be located on the X chromosome.

Original languageEnglish (US)
Pages (from-to)864-868
Number of pages5
JournalArchives of Dermatology
Volume121
Issue number7
DOIs
StatePublished - 1985
Externally publishedYes

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Epidermodysplasia Verruciformis
X-Linked Genes
Inheritance Patterns
Genetic Loci
Papillomavirus Infections
X Chromosome
Nuclear Family
X-Linked Epidermodysplasia Verruciformis

ASJC Scopus subject areas

  • Dermatology

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X-linked Inheritance of Epidermodysplasia Verruciformis : Genetic and Virologic Studies of a Kindred. / Androphy, Elliot; Dvoretzky, Israel; Lowy, Douglas R.

In: Archives of Dermatology, Vol. 121, No. 7, 1985, p. 864-868.

Research output: Contribution to journalArticle

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