Xenon-133 accumulation in hepatic steatosis

M. Ahmad, K. F. Witztum, J. W. Fletcher

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Observation of radioxenon accumulation in the liver of patients during routine pulmonary ventilation studies suggested that hepatic xenon accumulation might result from increased hepatic fat content. Hepatic xenon-133 accumulation was studied in paired rat litter mates, one with alcohol-induced fatty liver, the control fed isocaloric glucose. Xenon accumulation was increased in fatty livers and paralleled the amount of liver fat. During routine ventilation studies in 42 patients, hepatic xenon accumulation and retention were correlated with alcoholic drinking history and hepatic function studies. Of 15 patients without xenon accumulation, 1 had a drinking history. Of 13 patients with 1+ hepatic xenon, 5 had a drinking history, 3 were diabetic, 2 were obese, and 2 had elevated lipid levels. Of 6 patients with 2+ hepatic xenon, 4 had a drinking history, 1 had no drinking history recorded, and 1 was diabetic; 2 had abnormal liver-function studies. All 5 patients with 3+ hepatic xenon had a drinking history and abnormal liver function. Of three patients with 4+ hepatic xenon, 2 had a drinking history and abnormal liver function; the other was an obese diabetic. There was a parallel between the degree of hepatic xenon accumulation and the degree of suspected alcoholic fatty infiltration or diabetes determined from the clinical data. These results suggest the possible utility of hepatic radioxenon accumulation as a diagnostic test for fatty infiltration of the liver.

Original languageEnglish (US)
Pages (from-to)881-885
Number of pages5
JournalJournal of Nuclear Medicine
Volume18
Issue number9
StatePublished - Jan 1 1977
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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