XPC 939A>C and 499C>T polymorphisms and skin cancer risk: A meta-analysis

Geng Ji, Yuan Lin, Song Yu Cao, Luo Zhu Li, Xin Long Chen, Bu Mei Sun, Chuan Jun Chen, Hong Xia Ma

6 Scopus citations

Abstract

The xeroderma pigmentosum complementation group C gene (XPC) has been identified as important for repairing UV-related DNA damage. Some subtle changes in this gene may impair repair efficiency and influence susceptibility to human cancers, including skin cancer. Two polymorphisms in XPC, 939A>C (rs2228001) and 499C>T (rs2228000), are considered to have possible associations with the risk of skin cancer, but the reported results have been inconsistent. Here we performed a meta-analysis of the available evidence regarding the relationship between these two polymorphisms and the risk of skin cancer. All relevant studies were searched using PubMed, Embase and Web of Science before February 2012. A total of 8 case-control studies were included in this analysis, and no convincing associations between the two polymorphisms and risk of skin cancer were observed in any of the genetic models. Stratified analyses by skin cancer type also did not detect significant associations in any subgroup. This meta-analysis suggested that the XPC 939A>C and 499C>T polymorphisms may have little involvement in susceptibility to skin cancer.

Original languageEnglish (US)
Pages (from-to)4983-4988
Number of pages6
JournalAsian Pacific Journal of Cancer Prevention
Volume13
Issue number10
DOIs
StatePublished - 2012

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Keywords

  • Meta-analysis
  • Polymorphism
  • Skin cancer
  • XPC

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

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