YES, a src family kinase, is a proximal glucose-specific activator of cell division cycle control protein 42 (Cdc42) in pancreatic islet β cells

Stephanie M. Yoder, Stacey L. Dineen, Zhanxiang Wang, Debbie C. Thurmond

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Background: Although Cdc42 signaling is a known requirement for insulin secretion to occur, how it is initiated remains unknown. Results: YES kinase is required for Cdc42 activation in human islets and β cells. Conclusion: YES is a proximal, glucose-specific activator of Cdc42 and glucose-simulated insulin secretion. Significance: YES may provide a novel target for improvement of functional β cell mass.

Original languageEnglish (US)
Pages (from-to)11476-11487
Number of pages12
JournalJournal of Biological Chemistry
Volume289
Issue number16
DOIs
StatePublished - Apr 18 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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