YES, a src family kinase, is a proximal glucose-specific activator of cell division cycle control protein 42 (Cdc42) in pancreatic islet β cells

Stephanie M. Yoder, Stacey L. Dineen, Zhanxiang Wang, Debbie C. Thurmond

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Although Cdc42 signaling is a known requirement for insulin secretion to occur, how it is initiated remains unknown. Results: YES kinase is required for Cdc42 activation in human islets and β cells. Conclusion: YES is a proximal, glucose-specific activator of Cdc42 and glucose-simulated insulin secretion. Significance: YES may provide a novel target for improvement of functional β cell mass.

Original languageEnglish
Pages (from-to)11476-11487
Number of pages12
JournalJournal of Biological Chemistry
Volume289
Issue number16
DOIs
StatePublished - Apr 18 2014

Fingerprint

Cell Cycle Proteins
src-Family Kinases
Cell Cycle Checkpoints
Islets of Langerhans
Cells
Glucose
Insulin
Proteins
Phosphotransferases
Chemical activation

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

YES, a src family kinase, is a proximal glucose-specific activator of cell division cycle control protein 42 (Cdc42) in pancreatic islet β cells. / Yoder, Stephanie M.; Dineen, Stacey L.; Wang, Zhanxiang; Thurmond, Debbie C.

In: Journal of Biological Chemistry, Vol. 289, No. 16, 18.04.2014, p. 11476-11487.

Research output: Contribution to journalArticle

Yoder, Stephanie M. ; Dineen, Stacey L. ; Wang, Zhanxiang ; Thurmond, Debbie C. / YES, a src family kinase, is a proximal glucose-specific activator of cell division cycle control protein 42 (Cdc42) in pancreatic islet β cells. In: Journal of Biological Chemistry. 2014 ; Vol. 289, No. 16. pp. 11476-11487.
@article{1f82a341f80343da9a9269e11aee2fe4,
title = "YES, a src family kinase, is a proximal glucose-specific activator of cell division cycle control protein 42 (Cdc42) in pancreatic islet β cells",
abstract = "Background: Although Cdc42 signaling is a known requirement for insulin secretion to occur, how it is initiated remains unknown. Results: YES kinase is required for Cdc42 activation in human islets and β cells. Conclusion: YES is a proximal, glucose-specific activator of Cdc42 and glucose-simulated insulin secretion. Significance: YES may provide a novel target for improvement of functional β cell mass.",
author = "Yoder, {Stephanie M.} and Dineen, {Stacey L.} and Zhanxiang Wang and Thurmond, {Debbie C.}",
year = "2014",
month = "4",
day = "18",
doi = "10.1074/jbc.M114.559328",
language = "English",
volume = "289",
pages = "11476--11487",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "16",

}

TY - JOUR

T1 - YES, a src family kinase, is a proximal glucose-specific activator of cell division cycle control protein 42 (Cdc42) in pancreatic islet β cells

AU - Yoder, Stephanie M.

AU - Dineen, Stacey L.

AU - Wang, Zhanxiang

AU - Thurmond, Debbie C.

PY - 2014/4/18

Y1 - 2014/4/18

N2 - Background: Although Cdc42 signaling is a known requirement for insulin secretion to occur, how it is initiated remains unknown. Results: YES kinase is required for Cdc42 activation in human islets and β cells. Conclusion: YES is a proximal, glucose-specific activator of Cdc42 and glucose-simulated insulin secretion. Significance: YES may provide a novel target for improvement of functional β cell mass.

AB - Background: Although Cdc42 signaling is a known requirement for insulin secretion to occur, how it is initiated remains unknown. Results: YES kinase is required for Cdc42 activation in human islets and β cells. Conclusion: YES is a proximal, glucose-specific activator of Cdc42 and glucose-simulated insulin secretion. Significance: YES may provide a novel target for improvement of functional β cell mass.

UR - http://www.scopus.com/inward/record.url?scp=84899024508&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899024508&partnerID=8YFLogxK

U2 - 10.1074/jbc.M114.559328

DO - 10.1074/jbc.M114.559328

M3 - Article

VL - 289

SP - 11476

EP - 11487

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

SN - 0021-9258

IS - 16

ER -