You spin me round: MAFbx/Atrogin-1 feeds forward on FOXO transcription factors (like a record)

Jonathan C. Schisler, Monte S. Willis, Cam Patterson

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

Poly-ubiquitin chains are post-translational modifications commonly used by the ubiquitin-proteasome system to mark proteins for degradation. The regulation of protein degradation plays an important role in regulating muscle cell size, a cellular process balanced by protein synthesis and catabolism. MAFbx/ Atrogin-1, a muscle-specific F-box protein, is a principle component of the SCFatrogin-1 ubiquitin ligase complex that ubiquitinates and targets calcineurin for degradation, a key regulatory protein involved in pathologic hypertrophy. We have recently described a novel role for this ubiquitin ligase as a co-activator of the FOXO transcription factors through the catalysis of non-canonical poly-ubiquitin chain formation on FOXO proteins, an event that is sufficient to block Akt-dependent pathways involved in physiologic hypertrophy. In context with other reports describing the regulation and role of FOXO transcription factors, we present a working model for the role of atrogin-1 in both physiologic and pathologic hypertrophy.

Original languageEnglish (US)
Pages (from-to)440-443
Number of pages4
JournalCell Cycle
Volume7
Issue number4
DOIs
StatePublished - Feb 15 2008
Externally publishedYes

Keywords

  • Atrophy
  • Cardiac hypertrophy
  • Forkhead transcription factors
  • Ubiquitin chain formation
  • Ubiquitin ligase

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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