Yttrium 90 ibritumomab tiuxetan radioimmunotherapy for relapsed or refractory low-grade non-hodgkin's lymphoma

Leo I. Gordon, Thomas E. Witzig, Greg A. Wiseman, Ian W. Flinn, Stewart S. Spies, Daniel H. Silverman, Christos Emmanuolides, Larry Cripe, Mansoor Saleh, Myron S. Czuczman, Teresa Olejnik, Christine A. White, Antonio J. Grillo-López

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

The treatment of malignant lymphoma has improved over the past 20 years, but the majority of patients are not cured. New modalities using targeted therapy based on new information in molecular biology and immunology hold promise for better outcomes with less toxicity. We review data on the use of radiolabeled monoclonal antibodies directed against the CD20 antigen on malignant B cells. We discuss the major radionuclides available, iodine 131 (131I), tositumomab, and yttrium 90 (90Y) ibritumomab tiuxetan (Zevalin; IDEC Pharmaceuticals, San Diego, CA) and present data on new approaches in labeling antibodies that have facilitated their use. Clinical trial data with the yttrium-labeled antibodies are discussed. The use of dosimetry as a means for predicting toxicity is discussed, and the questions of long-term toxicity (late effects) are addressed. These targeted approaches to the treatment of malignancy, and lymphoma in particular, hold great promise.

Original languageEnglish (US)
Pages (from-to)87-92
Number of pages6
JournalSeminars in oncology
Volume29
Issue number1 SUPPL. 2
DOIs
StatePublished - 2002

ASJC Scopus subject areas

  • Hematology
  • Oncology

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