Zinc absorption from micronutrient powder is low but is not affected by iron in kenyan infants

Fabian Esamai, Edward Liechty, Justus Ikemeri, Jamie Westcott, Jennifer Kemp, Diana Culbertson, Leland V. Miller, K. Michael Hambidge, Nancy F. Krebs

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Interference with zinc absorption is a proposed explanation for adverse effects of supplemental iron in iron-replete children in malaria endemic settings. We examined the effects of iron in micronutrient powder (MNP) on zinc absorption after three months of home fortification with MNP in maize-based diets in rural Kenyan infants. In a double blind design, six-month-old, non-anemic infants were randomized to MNP containing 5 mg zinc, with or without 12.5 mg of iron (MNP + Fe and MNP − Fe, respectively); a control (C) group received placebo powder. After three months, duplicate diet collections and zinc stable isotopes were used to measure intake from MNP + non-breast milk foods and fractional absorption of zinc (FAZ) by dual isotope ratio method; total absorbed zinc (TAZ, mg/day) was calculated from intake × FAZ. Mean (SEM) TAZ was not different between MNP + Fe (n = 10) and MNP − Fe (n = 9) groups: 0.85 (0.22) and 0.72 (0.19), respectively, but both were higher than C (n = 9): 0.24 (0.03) (p = 0.04). Iron in MNP did not significantly alter zinc absorption, but despite intakes over double estimated dietary requirement, both MNP groups’ mean TAZ barely approximated the physiologic requirement for age. Impaired zinc absorption may dictate need for higher zinc doses in vulnerable populations.

Original languageEnglish
Pages (from-to)5636-5651
Number of pages16
JournalNutrients
Volume6
Issue number12
DOIs
StatePublished - Dec 8 2014

Fingerprint

Micronutrients
dietary minerals
Powders
Zinc
powders
Iron
zinc
iron
Zinc Isotopes
Diet
Nutritional Requirements
Vulnerable Populations
crossover interference
diet
malaria
Malaria
Zea mays
placebos
stable isotopes
isotopes

Keywords

  • Iron supplementation
  • Kenya
  • Malaria
  • Micronutrient powders
  • Zinc absorption

ASJC Scopus subject areas

  • Food Science

Cite this

Esamai, F., Liechty, E., Ikemeri, J., Westcott, J., Kemp, J., Culbertson, D., ... Krebs, N. F. (2014). Zinc absorption from micronutrient powder is low but is not affected by iron in kenyan infants. Nutrients, 6(12), 5636-5651. https://doi.org/10.3390/nu6125636

Zinc absorption from micronutrient powder is low but is not affected by iron in kenyan infants. / Esamai, Fabian; Liechty, Edward; Ikemeri, Justus; Westcott, Jamie; Kemp, Jennifer; Culbertson, Diana; Miller, Leland V.; Hambidge, K. Michael; Krebs, Nancy F.

In: Nutrients, Vol. 6, No. 12, 08.12.2014, p. 5636-5651.

Research output: Contribution to journalArticle

Esamai, F, Liechty, E, Ikemeri, J, Westcott, J, Kemp, J, Culbertson, D, Miller, LV, Hambidge, KM & Krebs, NF 2014, 'Zinc absorption from micronutrient powder is low but is not affected by iron in kenyan infants', Nutrients, vol. 6, no. 12, pp. 5636-5651. https://doi.org/10.3390/nu6125636
Esamai F, Liechty E, Ikemeri J, Westcott J, Kemp J, Culbertson D et al. Zinc absorption from micronutrient powder is low but is not affected by iron in kenyan infants. Nutrients. 2014 Dec 8;6(12):5636-5651. https://doi.org/10.3390/nu6125636
Esamai, Fabian ; Liechty, Edward ; Ikemeri, Justus ; Westcott, Jamie ; Kemp, Jennifer ; Culbertson, Diana ; Miller, Leland V. ; Hambidge, K. Michael ; Krebs, Nancy F. / Zinc absorption from micronutrient powder is low but is not affected by iron in kenyan infants. In: Nutrients. 2014 ; Vol. 6, No. 12. pp. 5636-5651.
@article{0e051e04e66e426f8cc80c9f318f3cd1,
title = "Zinc absorption from micronutrient powder is low but is not affected by iron in kenyan infants",
abstract = "Interference with zinc absorption is a proposed explanation for adverse effects of supplemental iron in iron-replete children in malaria endemic settings. We examined the effects of iron in micronutrient powder (MNP) on zinc absorption after three months of home fortification with MNP in maize-based diets in rural Kenyan infants. In a double blind design, six-month-old, non-anemic infants were randomized to MNP containing 5 mg zinc, with or without 12.5 mg of iron (MNP + Fe and MNP − Fe, respectively); a control (C) group received placebo powder. After three months, duplicate diet collections and zinc stable isotopes were used to measure intake from MNP + non-breast milk foods and fractional absorption of zinc (FAZ) by dual isotope ratio method; total absorbed zinc (TAZ, mg/day) was calculated from intake × FAZ. Mean (SEM) TAZ was not different between MNP + Fe (n = 10) and MNP − Fe (n = 9) groups: 0.85 (0.22) and 0.72 (0.19), respectively, but both were higher than C (n = 9): 0.24 (0.03) (p = 0.04). Iron in MNP did not significantly alter zinc absorption, but despite intakes over double estimated dietary requirement, both MNP groups’ mean TAZ barely approximated the physiologic requirement for age. Impaired zinc absorption may dictate need for higher zinc doses in vulnerable populations.",
keywords = "Iron supplementation, Kenya, Malaria, Micronutrient powders, Zinc absorption",
author = "Fabian Esamai and Edward Liechty and Justus Ikemeri and Jamie Westcott and Jennifer Kemp and Diana Culbertson and Miller, {Leland V.} and Hambidge, {K. Michael} and Krebs, {Nancy F.}",
year = "2014",
month = "12",
day = "8",
doi = "10.3390/nu6125636",
language = "English",
volume = "6",
pages = "5636--5651",
journal = "Nutrients",
issn = "2072-6643",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "12",

}

TY - JOUR

T1 - Zinc absorption from micronutrient powder is low but is not affected by iron in kenyan infants

AU - Esamai, Fabian

AU - Liechty, Edward

AU - Ikemeri, Justus

AU - Westcott, Jamie

AU - Kemp, Jennifer

AU - Culbertson, Diana

AU - Miller, Leland V.

AU - Hambidge, K. Michael

AU - Krebs, Nancy F.

PY - 2014/12/8

Y1 - 2014/12/8

N2 - Interference with zinc absorption is a proposed explanation for adverse effects of supplemental iron in iron-replete children in malaria endemic settings. We examined the effects of iron in micronutrient powder (MNP) on zinc absorption after three months of home fortification with MNP in maize-based diets in rural Kenyan infants. In a double blind design, six-month-old, non-anemic infants were randomized to MNP containing 5 mg zinc, with or without 12.5 mg of iron (MNP + Fe and MNP − Fe, respectively); a control (C) group received placebo powder. After three months, duplicate diet collections and zinc stable isotopes were used to measure intake from MNP + non-breast milk foods and fractional absorption of zinc (FAZ) by dual isotope ratio method; total absorbed zinc (TAZ, mg/day) was calculated from intake × FAZ. Mean (SEM) TAZ was not different between MNP + Fe (n = 10) and MNP − Fe (n = 9) groups: 0.85 (0.22) and 0.72 (0.19), respectively, but both were higher than C (n = 9): 0.24 (0.03) (p = 0.04). Iron in MNP did not significantly alter zinc absorption, but despite intakes over double estimated dietary requirement, both MNP groups’ mean TAZ barely approximated the physiologic requirement for age. Impaired zinc absorption may dictate need for higher zinc doses in vulnerable populations.

AB - Interference with zinc absorption is a proposed explanation for adverse effects of supplemental iron in iron-replete children in malaria endemic settings. We examined the effects of iron in micronutrient powder (MNP) on zinc absorption after three months of home fortification with MNP in maize-based diets in rural Kenyan infants. In a double blind design, six-month-old, non-anemic infants were randomized to MNP containing 5 mg zinc, with or without 12.5 mg of iron (MNP + Fe and MNP − Fe, respectively); a control (C) group received placebo powder. After three months, duplicate diet collections and zinc stable isotopes were used to measure intake from MNP + non-breast milk foods and fractional absorption of zinc (FAZ) by dual isotope ratio method; total absorbed zinc (TAZ, mg/day) was calculated from intake × FAZ. Mean (SEM) TAZ was not different between MNP + Fe (n = 10) and MNP − Fe (n = 9) groups: 0.85 (0.22) and 0.72 (0.19), respectively, but both were higher than C (n = 9): 0.24 (0.03) (p = 0.04). Iron in MNP did not significantly alter zinc absorption, but despite intakes over double estimated dietary requirement, both MNP groups’ mean TAZ barely approximated the physiologic requirement for age. Impaired zinc absorption may dictate need for higher zinc doses in vulnerable populations.

KW - Iron supplementation

KW - Kenya

KW - Malaria

KW - Micronutrient powders

KW - Zinc absorption

UR - http://www.scopus.com/inward/record.url?scp=84924874269&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84924874269&partnerID=8YFLogxK

U2 - 10.3390/nu6125636

DO - 10.3390/nu6125636

M3 - Article

VL - 6

SP - 5636

EP - 5651

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 12

ER -